SIU  Microbiology

David P. Clark

Map to Clark Website

Courses Taught:

Bacterial Physiology & Biochemistry (Micr425)
Introduction to Molecular Biology (Micr302)
Molecular Biology of Microorganisms Lab (Micr480)

My Molecular Biology Book:

Visit my publisher: Cache River Press for information on the book I wrote:
"Molecular Biology - made simple and fun" by David P. Clark & Lonnie D. Russell
Click here to see
Kelby and Dave planning the book.

Research Interests:

Anaerobic Growth and Fermentation in Escherichia coli

Jesse's Poster at the ASM Meeting, May 2000

Recent Publications:

To View Abstracts of All Publications Since 1996 Click Here

Clark D.P. and Cronan J.E. (1996) Two-Carbon Compounds and Fatty Acids as Carbon Sources. pp343-357 In: Neidhardt F.C., et al. (Eds.). Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. ASM. Washington D.C. 2nd edition.

Yong T-S., Li E., Clark, D.P. and Stanley S.L. (1996) Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a novel method for the identification of new anti-amebic drugs. Proc Natl Acad Sci USA 93: 6464-6469

Leonardo M. R., Dailly Y., and Clark, D.P. (1996) Role of NAD in regulating the adhE gene of Escherichia coli. J. Bacteriol. 178: 6013-6018

Bunch P.K. Mat-Jan F., Lee N., and Clark D.P. (1997) The ldhA gene encoding the fermentative lactate dehydrogenase of Escherichia coli. Microbiology 143: 187-195

Reams S.G., Lee N., Mat-Jan F., and Clark D.P. (1997) Effect of chelating agents and respiratory inhibitors on regulation of the cadA gene in Escherichia coli. Archives of Microbiology 167: 209-216

Nakano M M, Dailly Y P, Zuber P and Clark D P (1997) Characterization of anaerobic fermentative growth in Bacillus subtilis: Identification of fermentation end products and genes required for growth. J. Bacteriol. 179: 6749-6755

Donnelly M I, Millard C S, Clark D P, Chen M J and Rathke J W (1998) A novel fermentation pathway in an Escherichia coli mutant producing succinic acid, acetic acid and ethanol. Appl. Biochem. and Biotechnol. 70/72: 187-198

Bunch P K, Zabel M D and Clark D P (2000) Regulation of the thdF gene, which is involved in thiophene oxidation by Escherichia coli. Microbios 101: 89-103

Gupta S, Mat-Jan F, Latifi M and Clark D P (2000) Acetaldehyde dehydrogenase activity of the AdhE protein of Escherichia coli is inhibited by intermediates in ubiquinone synthesis. FEMS Letters 182: 51-55

Dailly Y P, Bunch P K and Clark D P (2000) Comparison of the fermentative alcohol dehydrogenases of Salmonella typhimurium and Escherichia coli. Microbios 103: 179-196

Holland-Staley C A, Lee KS, Clark D P and Cunningham P R (2000) Aerobic Activity of Escherichia coli Alcohol Dehydrogenase is Determined by a Single Amino Acid. J Bacteriol 182: 6094-6054

Chatterjee R, Millard C S, Champion K, Clark D P, and Donnelly M I (2001) Mutation of the ptsG gene results in Increased production of succinate in fermentation of glucose by Escherichia coli. Appl. Environ. Microbiol. 67: 148-154

Jiang G R, Nikolova S and Clark D P (2001) Regulation of the ldhA gene, encoding the fermentative lactate dehydrogenase of Escherichia coli. Microbiology 147: 2437-2446

Espinosa A, Yan L, Zhang Z, Foster L, Clark D P, Li E and Stanley S L (2001) The bifunctional Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) enzyme is necessary for amebic growth and survival and requires an intact and functional C-terminal domain for both alcohol dehydrogenase and acetaldehyde dehydrogenase activity. J Biol. Chem. 276: 20136-20143

Dailly Y P, Mat-Jan F and Clark D P (2001) Novel alcohol dehydrogenase activity in a mutant of Salmonella able to use ethanol as sole carbon source. FEMS Letts. 201: 41-45

Wachi M, Kaga N, Umitsuki G, Clark, D P and Nagai K (2001) A novel RNase G mutant that is defective in degradation of adhE mRNA but proficient in the processing of 16S rRNA precursor. Biochem. Biophys. Res. Commun. 289: 1301-1306

Parry J and Clark D P (2002) Identification of a CysB-regulated gene involved in glutathione transport in Escherichia coli. FEMS Microbiol. Letts. 209: 77-81

Kaga N, Umitsuki G, Clark D P, Nagai K and Wachi M (2002) Extensive overproduction of the AdhE protein by rng mutations depends on mutations in the cra gene or in the Cra-box of the adhE promoter. Biochem. Biophys. Res. Commun. 295: 92-97

Tired of science? Skip to Mutants Litter Box
Visit the World Famous Administrator Appreciation Area

by Dr. Seuss

did i ever tell you that mrs mccave
had twenty three sons and she named them all dave?
well, she did. and that wasnt a smart thing to do.
you see, when she wants one and calls out 'yoo-hoo!
come into the house, dave!' she doesnt get ONE.
all twenty three daves of hers come on the run!
this makes things quite difficult at the mccaves'
as you can imagine, with so many daves.

and often she wishes that, when they were born,
she had named one of them bodkin van horn
and one of them hoos-foos. and one of them snimm.
and one of them hot-shot. and one sunny jim.
and one of them shadrack. and one of them blinkey.
and one of them stuffy. and one of them stinkey.
another one putt-putt. another one moon face.
another one marvin o'gravel balloon face.
and one of them ziggy. and one soggy muff.
one buffalo bill. and one biffalo buff.
and one of them sneepy. and one weepy weed.
and one paris garters. and one harris tweed.
and one of them sir michael carmichael zutt
and one of them oliver boliver butt
and one of them zanzibar buck-buck mcfate...
but she didnt do it. and now its too late.

MY CAT, MUTANT

 


Visit Mutant's Litter Box

Mutant the cat passed away on July 2, 2002 due to a thyroid tumor. She was 16 years old.

Photo of Mutant Before She fell Ill

Comments and questions: clark@micro.siu.edu
Department of Microbiology e-mail: microbiology@micro.siu.edu
Comments and questions related to web server: webmaster@science.siu.edu


SIUC / College of Science / Microbiology / clark/
http://www.science.siu.edu/microbiology/clark/index.html
Last updated: June 2002 / dc