MICR 453 IMMUNOLOGY LECTURE

MICR 453 IMMUNOLOGY LECTURE - SPRING, 2008

Room 1059, LSIII Monday, Wednesday, Friday 10:00 a.m - 10:50 a.m.

Instructor: John Martinko LSII, Room 126. Phone: 536-2349

e-mail: martinko@micro.siu.edu

This page contains the syllabus and notes for week one of the course. Notes will be updated periodically and links will be added for all future material. I will make every effort to have the current version of the notes posted by the evening before each scheduled lecture or discussion period.

 Text: Murphy, K., Travers, P., and Walport, M. Janeway's Immunobiology, 7th edition. Garland Publishing Inc., 2008. Please bring your text to class. The illustrations from the text are used for most of the lecture material. Specific reading is assigned in the lecture schedule by chapter and section and will be updated as needed.

 Office hours: Tuesday and Thursday, 2:00-4:30 p.m. Office hours are for your benefit. If you need help or simply want to talk about course-related matters or immunology-related matters, please contact me. For Springfield students, please call or email. If you cannot come during office hours, please stop by or call if you have questions. You can also make an appointment to see me at a convenient time. I always respond to e-mail, an excellent way to get your questions to me.

SYLLABUS

MICR 453 IMMUNOLOGY LECTURE - SPRING, 2008

Room 1059, LSIII Monday, Wednesday, Friday 10:00 a.m - 10:50 a.m.

Instructor: John Martinko LSII, Room 126. Phone: 536-2349

e-mail: martinko@micro.siu.edu

Text: Murphy, K., Travers, P., and Walport, M. Janeway's Immunobiology. 7th edition. Garland Publishing Inc., 2008. Please bring your text to class. The illustrations from the text are used for most of the lecture material. Specific reading is assigned in the lecture schedule by chapter and section and will be updated as needed.

Course objectives: Students will understand the mechanisms involved in the immune response at the level of the molecules, cells, organs, and organisms. Students will be able to read and interpret popular and professional literature concerning the immune response.

Course format: Lectures will be based on the notes provided on the website. Questions and class discussions based on the lecture material are encouraged.

Web: Course information can be accessed from the micr453 link on the Microbiology website: http://www.micro.siu.edu/micr453/

The MICR 453 website will contain the current syllabus, tests from a previous year, and an outline of the notes. The website is updated periodically. A suggestion: download the notes, convert to a word-processing format, and expand/ enlarge them so that you can write directly on the outline in class.

Other Resources: Other reading material will be assigned at least one lecture in advance, as needed. Additional resource materials will be noted and placed on reserve in the Microbiology library (Room 131, LS II) or the Springfield graduate office as necessary.

Office hours: Tuesday and Thursday, 2:00-4:30 p.m. Office hours are for your benefit. If you need help, or simply want to talk about course matters or immunology, please contact me. For Springfield students, please call or email. If you cannot see me during office hours, please stop by or call if you have questions. You can also make an appointment to see me at a convenient time. I always respond to email, an excellent way to get your questions to me.

Grading: Tests and quizzes will be based on material from the lectures and discussions. There will be a 50 minute Prerequisite Quiz in week 2 covering introductory material (50 points), and Unannounced Quizzes of 5-25 points totaling 150 additional quiz points (Quiz total of 200 points). Unannounced Quizzes will be given at the end of lecture periods. Three 50-minute tests covering lectures 1-12, 13-24, and 25-37 (100 points each, total of 300 points), and a comprehensive final examination (100 points) comprise the graded work. The final examination will be cumulative and will include material from all lectures. The quizzes may include material from the three most recent class meetings. There will be no make-up quizzes. Letter grades will be based on the best 500 of the 600 possible points. Therefore, the lowest 100 points (one hourly exam, one-half of the quiz grades, or the final) will be “dropped” when computing your grade. Because of this policy, there will be no make-up examinations. This policy makes it possible for you to skip the final if you are satisfied with your grade.

Grading Summary:

Quizzes

Prerequisite 50

` Unannounced 150

Total quiz 200

Tests

Test1 100

Test 2 100

Test 3 100 Final 100

TOTAL POINTS 600

The grade will be computed after 1 test or one-half of quizzes is dropped (your worst 100 points). The grade will, therefore, be based on 500 points.

Grading scale: 90-100% (450-500 points) / 500 points A

80-89% (400-449 points) / 500 points B

70-79% (350-399 points) / 500 points C

60-69% (300-349 points) / 500 points D

0-59% (0-299 points) / 500 points F

The schedule and policies are guidelines and are subject to change.

Individual Grade Record:

Quiz grades:

Prerequisite quiz ___

Unannounced quizzes: ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___

___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___

Total Quiz pts: _______

Test 1: _______

Test 2: _______

Test 3: _______

Final: _______

Total test points: _______

Total points - (lowest test or quizzes) = Adjusted total points: _______

Adjusted total points / 500 = _______

Final Grade: _______

MICR 453 IMMUNOLOGY LECTURE

SCHEDULE of LECTURES and TESTS

Date

Day

Lecture

Title

Reading (Chapter<>

Section)

Lectures 1-5

Assays, Anatomy, Overview, and Innate Immunity

1/14/08

Introduction

Web notes

1/16/08

Immunoassays

Appendix I

1/18/08

Overview of Immunology

Chapter 1

1/23/08

Quiz 1- Chapter 1 (50 pts)

1/25/08

Innate immunity and pattern recognition Complement

2-1<>2-10

2-11<>2-22

1/28/08

Induced innate responses

2-23<>2-34

Lectures 6-12

Antigen binding molecules: Immunoglobulins,

T-cell receptors, and MHC proteins

1/30/08

B cell products: antibody structure and antigen binding

3-1<>3-9

2/1/08

T cell and APC products: TCR and MHC structure and expression

3-10<>3-14

2/4/08

TCR-MHC-Peptide binding

3-15<>3-19

2/6/08

Generation of B cell receptor diversity

4-1<>4-8

2/8/08

Generation of T cell receptor diversity

4-9<>4-10

2/11/08

Ig isotypes

4-11<>4-16

2/13/08